Please use this identifier to cite or link to this item:
https://elib.bsu.by/handle/123456789/250567
Title: | A Raman Spectroscopic Study of Thymoquinone Antitumor Action |
Authors: | Vcherashniaya, A. V. Martinovich, I. V. Martinovich, G. G. Shadyro, O. I. Cherenkevich, S. N. |
Keywords: | ЭБ БГУ::ЕСТЕСТВЕННЫЕ И ТОЧНЫЕ НАУКИ |
Issue Date: | 2020 |
Citation: | J. Appl. Spectrosc. (2020) Vol. 87, No. 3, P. 515-519. |
Abstract: | Fluorescence assay and Raman spectroscopy were used to study the mechanisms of action of 2-isopropyl-5-methyl-1,4-benzoquinone (thymoquinone) on HEp-2 human larynx carcinoma cells. Thymoquinone was found to have a more pronounced toxic effect than 1,4-benzoquinone and 2,3,5-trimethyl-1,4-benzoquinone. The action of thymoquinone leads to a decrease in the mitochondrial membrane potential and release of cytochrome c from the mitochondria, indicating activation of apoptosis of tumor cells through the mitochondrial-mediated pathway. These results indicate the possibility of using Raman spectroscopy in the study of programmed cell death. |
URI: | https://elib.bsu.by/handle/123456789/250567 |
DOI: | https://doi.org/10.1007/s10812-020-01032-z |
Appears in Collections: | Кафедра биофизики (статьи) |
Files in This Item:
File | Description | Size | Format | |
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2020_Raman spectroscopic study of thymoquinone antitumor action.pdf | 421,82 kB | Adobe PDF | View/Open |
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