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Please use this identifier to cite or link to this item: https://elib.bsu.by/handle/123456789/250567
Title: A Raman Spectroscopic Study of Thymoquinone Antitumor Action
Authors: Vcherashniaya, A. V.
Martinovich, I. V.
Martinovich, G. G.
Shadyro, O. I.
Cherenkevich, S. N.
Issue Date: 2020
Citation: J. Appl. Spectrosc. (2020) Vol. 87, No. 3, P. 515-519.
Abstract: Fluorescence assay and Raman spectroscopy were used to study the mechanisms of action of 2-isopropyl-5-methyl-1,4-benzoquinone (thymoquinone) on HEp-2 human larynx carcinoma cells. Thymoquinone was found to have a more pronounced toxic effect than 1,4-benzoquinone and 2,3,5-trimethyl-1,4-benzoquinone. The action of thymoquinone leads to a decrease in the mitochondrial membrane potential and release of cytochrome c from the mitochondria, indicating activation of apoptosis of tumor cells through the mitochondrial-mediated pathway. These results indicate the possibility of using Raman spectroscopy in the study of programmed cell death.
URI: https://elib.bsu.by/handle/123456789/250567
Scopus: https://doi.org/10.1007/s10812-020-01032-z
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