Search of possible reading frame shifts in genes

Abstract

The definition of a phase shift of triplet periodicity (TP) is introduced. The mathematical algorithm for detection of a phase shift of TP in nucleotide se-quences has been developed. The gene sequences from the Kegg-46 data bank were have been analyzed to search for genes with TP phase shifts. The presence of a phase shift of TP for 318329 genes (~10 % from the total number of genes in the Kegg-46 data bank) has been demonstrated. We show that TP phase shifts are determined by the shifts of a reading frame (RF) in genes. The connection between phase shifts of TP and RF shifts in genes is discussed.