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Title: Natural polysaccharides and their derivatives as potential medical materials and drug delivery systems for the treatment of peripheral nerve injuries(Review)
Authors: Solomevich, Solomevich, S.O.
Oranges, C.M.
Kalbermatten, D.F.
Schwendeman, A.
Madduri, S.
Keywords: ЭБ БГУ::ЕСТЕСТВЕННЫЕ И ТОЧНЫЕ НАУКИ::Химия
Issue Date: 2023
Publisher: Elsevier Ltd
Citation: Carbohydr Polym 2023; 315:120934.
Abstract: Peripheral nerve repair following injury is one of the most serious problems in neurosurgery. Clinical outcomes are often unsatisfactory and associated with a huge socioeconomic burden. Several studies have revealed the great potential of biodegradable polysaccharides for improving nerve regeneration. We review here the promising therapeutic strategies involving different types of polysaccharides and their bio-active composites for promoting nerve regeneration. Within this context, polysaccharide materials widely used for nerve repair in different forms are highlighted, including nerve guidance conduits, hydrogels, nanofibers and films. While nerve guidance conduits and hydrogels were used as main structural scaffolds, the other forms including nanofibers and films were generally used as additional supporting materials. We also discuss the issues of ease of therapeutic implementation, drug release properties and therapeutic outcomes, together with potential future directions of research
URI: https://elib.bsu.by/handle/123456789/305183
DOI: 10.1016/j.carbpol.2023.120934
Scopus: 2-s2.0-85158027189
Sponsorship: This work was supported by the Department of Surgery at Geneva University Hospitals and the University of Geneva , and the Geneva University Hospitals (HUG) Private Foundation for Research (RC08-21), Geneva, Switzerland.
Licence: info:eu-repo/semantics/openAccess
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