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Please use this identifier to cite or link to this item: https://elib.bsu.by/handle/123456789/240037
Title: Еhe effect of hypoxia on photocytotoxicity of tics tricarbocyanine dye in vitro
Authors: Istomin, Y. P.
Alexandrova, E. N.
Zhavrid, E. A.
Voropay, E. S.
Samtsov, M. P.
Kaplevsky, K. N.
Lugovsky, A. P.
Lugovsky, A. A.
Issue Date: 2006
Publisher: Украина: Киев
Citation: Experimental Oncology 28, 80–82, 2006 (March)
Abstract: Aim: To evaluate the effect of cell oxygenation onphotocytotoxicity of a novel tricarbocyanine indolenine dye covalently bound to glucose(TICS). Methods: HeLa cells were incubated with 5 μM TICS, 2 h later irradiated by laser at 740 nm with a light dose of 10 J/cm2, delivered at a power density of 10, 20, 25 or 30 mW/cm2, in air or in argon atmosphere, and then scored for viability. Results: The photocytotoxicity of TICS increased dramatically as the power density was reduced. Under hypoxia TICS-photosen-sitized cell death was determined but its value was lowered, compared to photoirradiation in the air. Conclusion: Photosensitizing effect of TICS is only partially dependent on the oxygenation of tumor cells.Key Words:photosensitizers, cyanine dyes, HeLa cells, photodynamic therapy, hypoxia.
URI: http://elib.bsu.by/handle/123456789/240037
Appears in Collections:Кафедра лазерной физики и спектроскопии

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