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|Title:||Plasmon-Enhanced WGM-based Biosensors for Molecule Detection|
|Authors:||Saetchnikov, V. A.|
Tcherniavskaia, E. A.
Saetchnikov, A. V.
|Keywords:||ЭБ БГУ::ЕСТЕСТВЕННЫЕ И ТОЧНЫЕ НАУКИ::Физика|
|Publisher:||Minsk : Education and Upbringing|
|Citation:||Nonlinear Phenomena in Complex Systems. - 2015. - Vol. 18, N 4. - P. 443-455|
|Abstract:||Novel technique based on optical resonance on microring structures, plasmon resonance and identiﬁcation tools has been developed. Experimental data on detection and identiﬁcation of variety of biochemical agents, such as proteins, microelements, antibiotics of diﬀerent generation etc. in both single and multicomponent solutions analyzed on the light scattering of whispering gallery mode optical resonance are represented. Multiplexing on parameters and components has been realized using developed ﬂuidic sensor cell with ﬁxed in adhesive layer dielectric microspheres and data processing. To improve sensitivity of microring structures microspheres had been treated previously by gold nanoparticle solution. Another technique included usage of thin ﬁlm gold layers deposited on the substrate below adhesive. Both biomolecule and nanoparticle injections cause considerable changes of optical resonance spectra. Plasmonic gold layers under optimized thickness also improve parameters of optical resonance spectra. Biochemical component identiﬁcation has been performed by developed network analysis techniques. Proposed approach is demonstrated to be applicable both for single agent and for multicomponent biochemical analysis. So advantages of plasmon enhancing optical microcavity resonance with multiparameter identiﬁcation tools have been used for development of a new platform for ulta-sensitive label-free biomedical sensor.|
|ISSN:||1561 - 4085|
|Appears in Collections:||2015. Volume 18. Number 4|
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