Please use this identifier to cite or link to this item:
https://elib.bsu.by/handle/123456789/212757
Title: | Fluorescence diagnosis of damage to tumor tissues during photodynamic therapy with the photosensitizer photolon |
Authors: | Samtsov, M. P. Tarasau, D. S. Kaplevsky, K. N. Voropay, E. S. Petrov, P. T. Istomin, Yu. P. |
Keywords: | ЭБ БГУ::ЕСТЕСТВЕННЫЕ И ТОЧНЫЕ НАУКИ::Физика |
Issue Date: | 2016 |
Publisher: | Springer |
Citation: | Journal of Applied Spectroscopy, Vol. 83, No. 1, March, 2016 |
Abstract: | We have studied the feasibility of using an indotricarbocyanine dye as a marker for the effi cacy of photodynamic therapy (PDT) of cancers with the photosensitizer Photolon®. We have established that on exposure to laser emission at λ = 667 nm with an exposure dose of 100 J/cm2, we observe that the Photolon® concentration drops by about a factor of two in the exposed part of the tumor, while the concentration of the indotricarbocyanine dye does not change in any region of the tumor node. We have observed a correlation between the change in the shape of the fluorescence spectra of the indotricarbocyanine dye in vivo in the 780–880 nm resulting from a PDT session with the photosensitizer Photolon® and the extent of damage to the tumor tissues. Changes in the shape of the fl uorescence spectrum of the dye are interpreted in terms of a model involving the appearance of absorption by different forms of hemoglobin, and changes in their ratio in the exposed part of the tumor due to consumption of molecular oxygen. |
URI: | http://elib.bsu.by/handle/123456789/212757 |
Appears in Collections: | Кафедра лазерной физики и спектроскопии (статьи) |
Files in This Item:
File | Description | Size | Format | |
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Samtsov2016_Article_FluorescenceDiagnosisOfDamageT.pdf | 383,25 kB | Adobe PDF | View/Open |
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