Please use this identifier to cite or link to this item:
|Title:||Fluorescence diagnosis of damage to tumor tissues during photodynamic therapy with the photosensitizer photolon|
|Authors:||Samtsov, M. P.|
Tarasau, D. S.
Kaplevsky, K. N.
Voropay, E. S.
Petrov, P. T.
Istomin, Yu. P.
|Keywords:||ЭБ БГУ::ЕСТЕСТВЕННЫЕ И ТОЧНЫЕ НАУКИ::Физика|
|Citation:||Journal of Applied Spectroscopy, Vol. 83, No. 1, March, 2016|
|Abstract:||We have studied the feasibility of using an indotricarbocyanine dye as a marker for the effi cacy of photodynamic therapy (PDT) of cancers with the photosensitizer Photolon®. We have established that on exposure to laser emission at λ = 667 nm with an exposure dose of 100 J/cm2, we observe that the Photolon® concentration drops by about a factor of two in the exposed part of the tumor, while the concentration of the indotricarbocyanine dye does not change in any region of the tumor node. We have observed a correlation between the change in the shape of the fluorescence spectra of the indotricarbocyanine dye in vivo in the 780–880 nm resulting from a PDT session with the photosensitizer Photolon® and the extent of damage to the tumor tissues. Changes in the shape of the fl uorescence spectrum of the dye are interpreted in terms of a model involving the appearance of absorption by different forms of hemoglobin, and changes in their ratio in the exposed part of the tumor due to consumption of molecular oxygen.|
|Appears in Collections:||Кафедра лазерной физики и спектроскопии|
Files in This Item:
|Samtsov2016_Article_FluorescenceDiagnosisOfDamageT.pdf||383,25 kB||Adobe PDF||View/Open|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.