Online determination of biophysical parameters of mucous membranes of a human body

Abstract

Quantum Electronics Russian Academy of Sciences logo. Turpion logo. Paper Online determination of biophysical parameters of mucous membranes of a human body

S.A. Lisenko and M.M. Kugeiko

© 2013 Kvantovaya Elektronika and Turpion Ltd Quantum Electronics, Volume 43, Number 7Citation S.A. Lisenko and M.M. Kugeiko 2013 Quantum Electron. 43 683DOI 10.1070/QE2013v043n07ABEH014951 Article metrics

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Abstract

We have developed a method for online determination of biophysical parameters of mucous membranes (MMs) of a human body (transport scattering coefficient, scattering anisotropy factor, haemoglobin concentration, degrees of blood oxygenation, average diameter of capillaries with blood) from measurements of spectral and spatial characteristics of diffuse reflection. The method is based on regression relationships between linearly independent components of the measured light signals and the unknown parameters of MMs, obtained by simulation of the radiation transfer in the MM under conditions of its general variability. We have proposed and justified the calibration-free fibre-optic method for determining the concentration of haemoglobin in MMs by measuring the light signals diffusely reflected by the tissue in four spectral regions at two different distances from the illumination spot. We have selected the optimal wavelengths of optical probing for the implementation of the method.