Radiation-Induced Transformations of 2-Fluoroethanol in Aqueous Solutions

Abstract

Steady-state radiolysis has been used to study the radiation-induced transformations of 2-fluoroethanol in dilute aqueous solutions as a model system for examining the autoradiolytic dehalogenation of the radiopharmaceutical drug 2-[18F]fluorodeoxyglucose ([18F]FDG). A derivatization–gas chromatography procedure for determining the fluoride anion in the presence of organofluorine compounds has been developed. It has been established that •OH and H• induced the dehalogenation of 2-fluoroethanol in aqueous solutions. Unlike bromo- and chlorohydrins, 2-fluoroethanol does not interact with e-aq according to the dissociative attachment mechanism. It has been shown that О2 halved the radiation-chemical yield of fluoride due to the oxidation of hydroxyl-containing carbon-centered radicals of 2-fluoroethanol. The constant of unimolecular dehalogenation of the 2-fluoroethanol radical is 3.9 × 106 s−1, as calculated using the method of competing reactions.