Cytokine profile analysis of convalescent COVID-19 plasma: implications for patient outcomes and therapeutic optimization

Abstract

Convalescent COVID-19 plasma (CCP) therapy holds promise as a treatment avenue for SARS-CoV-2-infected patients. Despite its potential, the efficacy of CCP therapy remains debated, necessitating a deeper investigation into its mechanisms. In this retrospective study, we aimed to elucidate the role of cytokines within CCP and their association with patient outcomes. Through comprehensive cytokine profiling and statistical analysis, we found specific cytokine patterns, particularly elevated levels of interleukin-6 (IL-6) and interferon-gamma (IFN-γ) in CCP, to be associated with adverse patient outcomes. Moreover, our subgroup analyses based on disease severity, comorbidities, and CCP donor characteristics revealed nuanced relationships between cytokine profiles and treatment responses, underscoring the importance of personalized therapeutic strategies in optimizing CCP therapy for COVID-19 patients. These findings provide valuable insights into the potential utility of cytokine profiling in predicting therapeutic responses and guiding treatment optimization for COVID-19