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Please use this identifier to cite or link to this item: https://elib.bsu.by/handle/123456789/289992
Title: Silver(I) complexes with phenolic Schiff bases: Synthesis, anti-bacterial evaluation and interaction with biomolecules
Authors: Loginova, Natalia
Gvozdev, Maxim
Osipovich, Nikolai
Khodosovskaya, Alina
Koval’chuk-Rabchinskaya, Tatiana
Ksendzova, Galina
Kotsikau, Dzmitry
Evtushenkov, Anatoly
Issue Date: 2022
Publisher: International Association of Physical Chemists
Citation: ADMET DMPK 2022;10(3):197-212.
Abstract: Novel Ag(I) complexes (2a–2c) with phenolic Schiff bases were synthesized using 4,6-di-tert-butyl-3-(((5-mercapto-1,3,4-thiadiazol-2-yl)imino)methyl)benzene-1,2-diol (1a), 4,6-di-tert-butyl-3-(((4-mercaptophe-nyl)imino)methyl)benzene-1,2-diol (1b), and 4,6-di-tert-butyl-3-(((3-mercaptophenyl)imino)methyl)-benzene-1,2-diol (1c). They were examined by elemental analysis, FT-IR, UV-Vis, 1H-NMR spectroscopy, XRD, cyclic voltammetry, conductivity measurements, and biological methods. The complexes are characterized by distorted geometry of the coordination cores AgN2S2 (2c), AgNS (2b) and AgS2 (2a). These stable complexes were not typified by the intramolecular redox reaction in organic solvents resulting in the formation of silver nanoparticles (AgNPs). Antibacterial activity of 1a–1c and 2a–2c was evaluated in comparison with AgNPs and commonly used antibiotics. All the complexes were more active than the ligands against the bacteria tested (14), but they were less active than AgNPs and commonly used antibiotics. Both 1a–1c and their complexes 2a–2c exhibited the capability for the bovine heart Fe(III)-Cyt c reduction. The ligands 1b and 1c were characterized by the highest reduction rate among the compounds under study, and they showed a higher reducing ability (determined by cyclic voltammetry) as compared with that of their Ag(I) complexes 2b and 2c.
URI: https://elib.bsu.by/handle/123456789/289992
DOI: 10.5599/admet.1167
Scopus: 85138213954
Licence: info:eu-repo/semantics/openAccess
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