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https://elib.bsu.by/handle/123456789/288246
Заглавие документа: | New insight into the mechanism of drug release from poly(D,l-lactide) film by electron paramagnetic resonance |
Авторы: | Chumakova, Natalia A. Golubeva, Elena N. Kuzin, Sergei V. Ivanova, Tatiana A. Grigoriev, Igor A. Kostjuk, Sergey V. Melnikov, Mikhail Ya. |
Тема: | ЭБ БГУ::ЕСТЕСТВЕННЫЕ И ТОЧНЫЕ НАУКИ::Химия |
Дата публикации: | 2020 |
Издатель: | MDPI AG |
Библиографическое описание источника: | Polym 2020;12(12):1-21. |
Аннотация: | A novel approach based on convolution of the electron paramagnetic resonance (EPR) spectra was used for quantitative study of the release kinetics of paramagnetic dopants from poly(D,L-lactide) films. A non-monotonic dependence of the release rate on time was reliably recorded. The release regularities were compared with the dynamics of polymer structure changes determined by EPR, SEM, and optic microscopy. The data obtained allow for the conclusion that the main factor governing dopant release is the formation of pores connected with the surface. In contrast, the contribution of the dopant diffusion through the polymer matrix is negligible. The dopant release can be divided into two phases: release through surface pores, which are partially closed with time, and release through pores initially formed inside the polymer matrix due to autocatalytic hydrolysis of the polymer and gradually connected to the surface of the sample. For some time, these processes co-occur. The mathematical model of the release kinetics based on pore formation is presented, describing the kinetics of release of various dopants from the polymer films of different thicknesses. |
URI документа: | https://elib.bsu.by/handle/123456789/288246 |
DOI документа: | 10.3390/polym12123046 |
Scopus идентификатор документа: | 85098072260 |
Финансовая поддержка: | This work was supported by the Russian Foundation for Basic Research (grant 18-29-06059), by the Russian Science Foundation (grant 19-13-00235 in part of spin probes synthesis), and in part by M.V. Lomonosov Moscow State University Program of Development. |
Лицензия: | info:eu-repo/semantics/openAccess |
Располагается в коллекциях: | Статьи химического факультета |
Полный текст документа:
Файл | Описание | Размер | Формат | |
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polymers_12_03046_pdf.pdf | 5,28 MB | Adobe PDF | Открыть |
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