Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на этот документ:
https://elib.bsu.by/handle/123456789/265379
Заглавие документа: | Analysis of thyroid malignant pathologic findings identified during 3 rounds of screening (1997-2008) of a cohort of children and adolescents from Belarus exposed to radioiodines after the Chernobyl accident |
Авторы: | Zablotska, L.B. Nadyrov, E.A. Rozhko, A.V. Gong, Z. Polyanskaya, O.N. McConnell, R.J. O'Kane, P. Brenner, A.V. Little, M.P. Ostroumova, E. Bouville, A. Drozdovitch, V. Minenko, V. Demidchik, Y. Nerovnya, A. Yauseyenka, V. Savasteeva, I. Nikonovich, S. Mabuchi, K. Hatch, M. |
Тема: | ЭБ БГУ::ЕСТЕСТВЕННЫЕ И ТОЧНЫЕ НАУКИ::Физика |
Дата публикации: | 2015 |
Издатель: | John Wiley and Sons Inc. |
Библиографическое описание источника: | Cancer 2015;121(3):457-466. |
Аннотация: | Recent studies of children and adolescents who were exposed to radioactive iodine-131 (I-131) after the 1986 Chernobyl nuclear accident in Ukraine exhibited a significant dose-related increase in the risk of thyroid cancer, but the association of radiation doses with tumor histologic and morphologic features is not clear. METHODS: A cohort of 11,664 individuals in Belarus who were aged ≤18 years at the time of the accident underwent 3 cycles of thyroid screening during 1997 to 2008. I-131 thyroid doses were estimated from individual thyroid activity measurements taken within 2 months after the accident and from dosimetric questionnaire data. Demographic, clinical, and tumor pathologic characteristics of the patients with thyroid cancer were analyzed using 1-way analysis of variance, chi-square tests or Fisher exact tests, and logistic regression. RESULTS: In total, 158 thyroid cancers were identified as a result of screening. The majority of patients had T1a and T1b tumors (93.7%), with many positive regional lymph nodes (N1; 60.6%) but few distant metastases (M1; <1%). Higher I-131 doses were associated with higher frequency of solid and diffuse sclerosing variants of thyroid cancer (P < .01) and histologic features of cancer aggressiveness, such as lymphatic vessel invasion, intrathyroidal infiltration, and multifocality (all P < .03). Latency was not correlated with radiation dose. Fifty-two patients with self-reported thyroid cancers which were diagnosed before 1997 were younger at the time of the accident and had a higher percentage of solid variant cancers compared with patients who had screening-detected thyroid cancers (all P < .0001). CONCLUSIONS: I-131 thyroid radiation doses were associated with a significantly greater frequency of solid and diffuse sclerosing variants of thyroid cancer and various features of tumor aggressiveness. |
URI документа: | https://elib.bsu.by/handle/123456789/265379 |
DOI документа: | 10.1002/cncr.29073 |
Scopus идентификатор документа: | 84921523555 |
Финансовая поддержка: | National Cancer Institute; National Cancer Institute (NCI), K07CA132918,ZIACP010132 |
Располагается в коллекциях: | Статьи НИУ «Институт ядерных проблем» |
Полный текст документа:
Файл | Описание | Размер | Формат | |
---|---|---|---|---|
cncr.29073.pdf | 298,49 kB | Adobe PDF | Открыть |
Все документы в Электронной библиотеке защищены авторским правом, все права сохранены.