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Заглавие документа: Risk of Thyroid Follicular Adenoma Among Children and Adolescents in Belarus Exposed to Iodine-131 After the Chornobyl Accident
Авторы: Zablotska, L.B.
Nadyrov, E.A.
Polyanskaya, O.N.
McConnell, R.J.
O'Kane, P.
Lubin, J.
Hatch, M.
Little, M.P.
Brenner, A.V.
Veyalkin, I.V.
Yauseyenka, V.V.
Bouville, A.
Drozdovitch, V.V.
Minenko, V.F.
Demidchik, Y.E.
Mabuchi, K.
Rozhko, A.V.
Тема: ЭБ БГУ::ЕСТЕСТВЕННЫЕ И ТОЧНЫЕ НАУКИ::Физика
Дата публикации: 2015
Издатель: Oxford University Press
Библиографическое описание источника: Am J Epidemiol 2015;182(9):781-790.
Аннотация: Several studies reported an increased risk of thyroid cancer in children and adolescents exposed to radioactive iodines, chiefly iodine-131 (131I), after the 1986 Chornobyl (Ukrainian spelling) nuclear power plant accident. The risk of benign thyroid tumors following such radiation exposure is much less well known. We have previously reported a novel finding of significantly increased risk of thyroid follicular adenoma in a screening study of children and adolescents exposed to the Chornobyl fallout in Ukraine. To verify this finding, we analyzed baseline screening data from a cohort of 11,613 individuals aged ≤18 years at the time of the accident in Belarus (mean age at screening = 21 years). All participants had individual 131I doses estimated from thyroid radioactivity measurements and were screened according to a standardized protocol. We found a significant linear dose response for 38 pathologically confirmed follicular adenoma cases. The excess odds ratio per gray of 2.22 (95% confidence interval: 0.41, 13.1) was similar in males and females but decreased significantly with increasing age at exposure (P < 0.01), with the highest radiation risks estimated for those exposed at <2 years of age. Follicular adenoma radiation risks were not significantly modified by most indicators of past and current iodine deficiency. The present study confirms the 131I-associated increases in risk of follicular adenoma in the Ukrainian population and adds new evidence on the risk increasing with decreasing age at exposure.
URI документа: https://elib.bsu.by/handle/123456789/264642
DOI документа: 10.1093/aje/kwv127
Scopus идентификатор документа: 84947583155
Финансовая поддержка: National Cancer Institute (grant CA132918 to L.B.Z.; contract NO1-CP-21178 with L.B.Z., R.J.M., and P.O.; and funds from the Intramural Research Program of the Division of Cancer Epidemiology and Genetics to J.L., M.H., M.P.L., A.V.B., A.B., V.V.D., and K.M.). The US Department of Energy provided funding at the earlier stages of the study, and the Nuclear Regulatory Commission provided the initial funds for purchase of equipment.
Располагается в коллекциях:Статьи НИУ «Институт ядерных проблем»

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