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Please use this identifier to cite or link to this item: https://elib.bsu.by/handle/123456789/261156
Title: Polyisobutylene-based thermoplastic elastomers for manufacturing polymeric heart valve leaflets: In vitro and in vivo results
Authors: Ovcharenko, E.
Rezvova, M.
Nikishau, P.
Kostjuk, S.
Glushkova, T.
Antonova, L.
Trebushat, D.
Akentieva, T.
Shishkova, D.
Krivikina, E.
Klyshnikov, K.
Kudryavtseva, Y.
Issue Date: 2019
Publisher: MDPI AG
Citation: Appl Sci 2019;9(22)
Abstract: Superior polymers represent a promising alternative to mechanical and biological materials commonly used for manufacturing artificial heart valves. The study is aimed at assessing poly(styrene-block-isobutylene-block-styrene) (SIBS) properties and comparing them with polytetrafluoroethylene (Gore-texTM, a reference sample). Surface topography of both materials was evaluated with scanning electron microscopy and atomic force microscopy. The mechanical properties were measured under uniaxial tension. The water contact angle was estimated to evaluate hydrophilicity/hydrophobicity of the study samples. Materials' hemocompatibility was evaluated using cell lines (Ea.hy 926), donor blood, and in vivo. SIBS possess a regular surface relief. It is hydrophobic and has lower strength as compared to Gore-texTM (3.51 MPa vs. 13.2/23.8 MPa). SIBS and Gore-texTM have similar hemocompatibility (hemolysis, adhesion, and platelet aggregation). The subcutaneous rat implantation reports that SIBS has a lower tendency towards calcification (0.39 mg/g) compared with Gore-texTM (1.29 mg/g). SIBS is a highly hemocompatible material with a promising potential for manufacturing heart valve leaflets, but its mechanical properties require further improvements. The possible options include the reinforcement with nanofillers and introductions of new chains in its structure.
URI: https://elib.bsu.by/handle/123456789/261156
Scopus: 10.3390/app9224773
metadata.dc.identifier.scopus: 85075254679
Sponsorship: Russian Science Foundation (RSF),18-75-10061. The research was funded by a grant from the Russian Science Foundation (project No. 18-75-10061).
Appears in Collections:Статьи химического факультета

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