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Please use this identifier to cite or link to this item: https://elib.bsu.by/handle/123456789/259464
Title: Temoporfin-in-cyclodextrin-in-liposome—a new approach for anticancer drug delivery: The optimization of composition
Authors: Yakavets, I.
Lassalle, H.-P.
Scheglmann, D.
Wiehe, A.
Zorin, V.
Bezdetnaya, L.
Issue Date: 2018
Publisher: MDPI AG
Citation: Nanomaterials 2018;8(10)
Abstract: The main goal of this study was to use hybrid delivery system for effective transportation of temoporfin (meta-tetrakis(3-hydroxyphenyl)chlorin mTHPC) to target tissue. We suggested to couple two independent delivery systems (liposomes and inclusion complexes) to achieve drug-in-cyclodextrin-in-liposome (DCL) nanoconstructs. We further optimized the composition of DCLs aiming to alter in a more favorable way a distribution of temoporfin in tumor tissue. We have prepared DCLs with different compositions varying the concentration of mTHPC and the type of β-cyclodextrin (β-CD) derivatives (Hydroxypropyl- Methyl- and Trimethylβ-CD). DCLs were prepared by thin-hydration technique and mTHPC/β-CD complexes were added at hydration step. The size was about 135 nm with the surface charge of (-38 mV).We have demonstrated that DCLs are stable and almost all mTHPC is bound to β-CDs in the inner aqueous liposome core. Among all tested DCLs trimethyl-β-CD-based DCL demonstrated a homogenous accumulation of mTHPC across tumor spheroid volume thus supposing optimal mTHPC distribution.
URI: https://elib.bsu.by/handle/123456789/259464
Scopus: 10.3390/nano8100847
metadata.dc.identifier.scopus: 85056316126
Appears in Collections:Кафедра биофизики

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