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|Title:||Binding of poly(amidoamine), carbosilane, phosphorus and hybrid dendrimers to thrombin—Constants and mechanisms|
de la Mata, F. J.
|Keywords:||ЭБ БГУ::ЕСТЕСТВЕННЫЕ И ТОЧНЫЕ НАУКИ|
|Citation:||Colloids Surf B Biointerfaces 2017;155:11-16.|
|Abstract:||Thrombin is an essential part of the blood coagulation system; it is a serine protease that converts soluble fibrinogen into insoluble strands of fibrin, and catalyzes many other coagulation-related reactions. Absorption at its surface of small nanoparticles can completely change the biological properties of thrombin. We have analyzed the influence on thrombin of 3 different kinds of small nanoparticles: dendrimers (phosphorus-based, carbosilane based and polyamidoamine) and 2 hybrid systems containing carbosilane, viologen and phosphorus dendritic scaffolds in one single molecule, bearing different flexibility, size and surface charge. There was significant alteration in the rigidity of the rigid dendrimers in contrast to flexible dendrimers. These differences in their action are important in understanding interactions taking place at a bio-nanointerface.|
|Sponsorship:||This work was supported by the National Science Centre of Poland, Project No. DEC-2012/04/M/NZ1/00059, and by the Belarusian Republican Foundation for Fundamental Research, grants B15MS-001 and B16-071. This work was also supported by the Spanish Ministry of Economy and Competitiveness (ref. CTQ-2014-54004-P) and University of Alcal? (ref. CCG2016/EXP-052). CIBER-BBN is an initiative funded by the VI National R&D&i Plan 2008?2011, Iniciativa Ingenio 2010, Consolider Program, CIBER Actions and financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund.|
|Appears in Collections:||Кафедра биофизики|
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