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Please use this identifier to cite or link to this item: https://elib.bsu.by/handle/123456789/258360
Title: Drug delivery to solid tumors: The predictive value of the multicellular tumor spheroid model for nanomedicine screening
Authors: Yakavets, I.
Zorin, V.
Keywords: ЭБ БГУ::ЕСТЕСТВЕННЫЕ И ТОЧНЫЕ НАУКИ::Физика
ЭБ БГУ::ЕСТЕСТВЕННЫЕ И ТОЧНЫЕ НАУКИ::Биология
ЭБ БГУ::ТЕХНИЧЕСКИЕ И ПРИКЛАДНЫЕ НАУКИ. ОТРАСЛИ ЭКОНОМИКИ::Медицина и здравоохранение
Issue Date: 2017
Publisher: Dove Medical Press Ltd.
Citation: Nanomed 2017;12:7993-8007
Abstract: The increasing number of publications on the subject shows that nanomedicine is an attractive field for investigations aiming to considerably improve anticancer chemotherapy. Based on selective tumor targeting while sparing healthy tissue, carrier-mediated drug delivery has been expected to provide significant benefits to patients. However, despite reduced systemic toxicity, most nanodrugs approved for clinical use have been less effective than previously antici­pated. The gap between experimental results and clinical outcomes demonstrates the necessity to perform comprehensive drug screening by using powerful preclinical models. In this context, in vitro three-dimensional models can provide key information on drug behavior inside the tumor tissue. The multicellular tumor spheroid (MCTS) model closely mimics a small avascular tumor with the presence of proliferative cells surrounding quiescent cells and a necrotic core. Oxygen, pH and nutrient gradients are similar to those of solid tumor. Furthermore, extracellular matrix (ECM) components and stromal cells can be embedded in the most sophisticated spheroid design. All these elements together with the physicochemical properties of nanoparticles (NPs) play a key role in drug transport, and therefore, the MCTS model is appropriate to assess the ability of NP to penetrate the tumor tissue. This review presents recent developments in MCTS models for a better comprehension of the interactions between NPs and tumor components that affect tumor drug delivery. MCTS is particularly suitable for the high-throughput screening of new nanodrugs
URI: https://elib.bsu.by/handle/123456789/258360
Scopus: 10.2147/IJN.S146927
metadata.dc.identifier.scopus: 85033581064
Sponsorship: Institut de Cancérologie de Lorraine (ICL) This work was supported by the French “Ligue Nationale contre le Cancer (CCIR-GE)” and the Institut de Cancérologie de Lorraine. Aigul Kulmukhamedova acknowledges the JCS “Center for International Programs”, Kazakhstan, for financial support.
Appears in Collections:Кафедра биофизики

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