Белки сократительных систем как диагностические маркеры злокачественных опухолей

Abstract

The major components of cytoskeletal and contractile systems (actin and myosin) are involved in a broad range of cellular events - cytokinesis, secretion, motility. Malignization results in dramatic alteration of the cellular molecular biology, including organization of the cytoskeletal and contractile elements. In this review, we explore the role of actin and myosin in the expression of transformed phenotype, analyze experimental data concerning biochemical properties of actin and myosin, regulatory mechanisms of actin-myosin interaction, expression of actin isoforms and myosin subunits in malignant tumors of different origin. Taken together, the existing data seem to confirm diagnostic value of actin and myosin isoforms analysis and provide new information on the histogenetic origin and the degree of differentiation of malignant tumors