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https://elib.bsu.by/handle/123456789/233400
Заглавие документа: | A random graph generation model for transcription networks and nonparametric simulator for RNA-seq expression data |
Авторы: | Grimes, T. Datta, S. |
Тема: | ЭБ БГУ::ЕСТЕСТВЕННЫЕ И ТОЧНЫЕ НАУКИ::Математика ЭБ БГУ::ЕСТЕСТВЕННЫЕ И ТОЧНЫЕ НАУКИ::Кибернетика |
Дата публикации: | 2019 |
Издатель: | Minsk : BSU |
Библиографическое описание источника: | Computer Data Analysis and Modeling: Stochastics and Data Science : Proc. of the Twelfth Intern. Conf., Minsk, Sept. 18-22, 2019. – Minsk : BSU, 2019. – P. 37-42. |
Аннотация: | With the advent of high-throughput sequencing and continually decreasing costs, an abundance of gene expression data has been generated and is available for analysis. These data provide a rich resource for inferring connections in gene regulatory networks. A vast collection of methodologies have been developed, but a challenge remains in assessing and benchmarking their performance. Gold-standard datasets are scarce, and commonly-used simulators are not designed to resemble the data generated from RNA-seq experiments. The present study provides a novel random graph generator that produces networks having comparable topology to transcription networks. In addition, a nonparametric simulator is proposed that generates conditionally dependent expression data; the conditional dependencies are based on an underlying network structure, and the marginal distribution of gene expression profiles are based on a reference RNA-seq dataset. These methods provide tools for creating in silico RNA-seq data for benchmarking and assessing gene network inference methods. Keywords: data science, random graph, transcription network, RNA expression |
URI документа: | http://elib.bsu.by/handle/123456789/233400 |
ISBN: | 978-985-566-811-5 |
Располагается в коллекциях: | 2019. Computer Data Analysis and Modeling : Stochastics and Data Science |
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