использование диаденозинтетрафосфата для снижения повышенной агрегационной способности тромбоцитов при гипертензивных состояниях

Abstract

This work is dedicated to detection and subsequent study of signal & regulatory violations of the functional activity of platelets in hypertensive disorders and the methods of their correction. The role of H2O2 in changing of functional activity of platelets was investigated. The derived data allow redefining the concept of the cytotoxic effects of active oxygen forms in platelets and the role of oxidative stress in the initiation of preeclampsia. In an organism of pregnant women with preeclampsia increases the sensitivity to signal & regulatory effects of H2O2. It is shown that in platelets of pregnant women with preeclampsia the level of calcium remains within normal physiological limits and the ability to reduce it retains by the action of some effectors, which allowed the use of ATP, Ap4A for reducing the increased platelets aggregation.The derived data are of interest for clinicians, working in the field of gynecology and obstetrics