Морфофункциональные изменения в мотонейронах спинного мозга при подпеченочном холестазе

Abstract

Experimental full cholestasis at rats in dynamics (2, 5, 10, 20, 45 and 90 day) causes significant changes morphological and histochemical the parameters reflecting a functional condition neurons lateral and medial kernels of forward horns of a spinal cord. The increase in volume, the area and perimeter neurons and their kernels is registered, and these changes are more expressed in lateral a kernel, rather than in medial. Thus the form neurons changes: there is their some elongation – from rather spherical forms they become more extended. All this testifies to negative influence full cholestatic on one of ancient structures CNS. Probably, it is one of the reasons of observable neurologic frustration at people at full cholestasis diseases