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Please use this identifier to cite or link to this item: https://elib.bsu.by/handle/123456789/212757
Title: Fluorescence diagnosis of damage to tumor tissues during photodynamic therapy with the photosensitizer photolon
Authors: Samtsov, M. P.
Tarasau, D. S.
Kaplevsky, K. N.
Voropay, E. S.
Petrov, P. T.
Istomin, Yu. P.
Issue Date: 2016
Publisher: Springer
Citation: Journal of Applied Spectroscopy, Vol. 83, No. 1, March, 2016
Abstract: We have studied the feasibility of using an indotricarbocyanine dye as a marker for the effi cacy of photodynamic therapy (PDT) of cancers with the photosensitizer Photolon®. We have established that on exposure to laser emission at λ = 667 nm with an exposure dose of 100 J/cm2, we observe that the Photolon® concentration drops by about a factor of two in the exposed part of the tumor, while the concentration of the indotricarbocyanine dye does not change in any region of the tumor node. We have observed a correlation between the change in the shape of the fluorescence spectra of the indotricarbocyanine dye in vivo in the 780–880 nm resulting from a PDT session with the photosensitizer Photolon® and the extent of damage to the tumor tissues. Changes in the shape of the fl uorescence spectrum of the dye are interpreted in terms of a model involving the appearance of absorption by different forms of hemoglobin, and changes in their ratio in the exposed part of the tumor due to consumption of molecular oxygen.
URI: http://elib.bsu.by/handle/123456789/212757
Appears in Collections:Кафедра лазерной физики и спектроскопии

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