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https://elib.bsu.by/handle/123456789/197255| Title: | Белки острой фазы как вероятные регуляторы лихорадочной реакции |
| Authors: | Сандаков, Дмитрий Борисович Гурин, Александр Валерьевич Гурин, Валерий Николаевич |
| Keywords: | ЭБ БГУ::ЕСТЕСТВЕННЫЕ И ТОЧНЫЕ НАУКИ::Биология |
| Issue Date: | 2001 |
| Publisher: | Минск : БГУ |
| Citation: | Вестник Белорусского государственного университета. Сер. 2, Химия. Биология. География. – 2001. - № 3. – С. 81-84. |
| Abstract: | It suggested that acute phase proteins (APP) are not only nonspecific tissue protectors, but also regulators of febrile response. The experimental verification of this hypothsis demonstrated: (1) APP di-antitrypsin (oAT) and аг-macroglobulin (aMG) elevate body temperature in mice, rats and rabbits; (2) aMG attenuates body temperature responses to endotoxin; (3) Hyperthermia produced by ar antitrypsin or d2-macroglobulin is followed by an increased blood level of interleukin-6; (4) Antipyretic effect of aMG is accompanied by an elevation of tumor necrosis factor activity in blood; (5) APP aAT and aMG stimulate production of interleukin-6 and tumor necrosis factor by blood mononuclear cells in vitro. |
| URI: | http://elib.bsu.by/handle/123456789/197255 |
| ISSN: | 0372-5340 |
| Licence: | info:eu-repo/semantics/openAccess |
| Appears in Collections: | 2001, №3 (октябрь) |
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