IR Fourier–Spectroscopy and Pharmacological Properties of Phenols

Abstract

IR Fourier spectra of pharmacologically active phenol molecules in solutions and crystals in CCl4 are studied. The analysis of the screened phenols has shown that phenols with free hydroxyl groups possess the most antimicrobial activity. The manifestation of antiviral activity of aminophenols is associated with forming intramolecular hydrogen bonds in solutions. Phenyl-containing aminophenols, which have high activity against herpes virus, are characterized by the formation of the O-H...N-type intramolecular hydrogen bond. The main sign of high activity of aminophenols against group A virus is the predominance of the O-H...O=C-type intramolecular hydrogen bond. Sulfur-containing aminophenols, which show their activity against HIV-infection, have hydrogen bonds with O-H-, N-H- and SO2 -groups in solutions and crystals.