Please use this identifier to cite or link to this item:
https://elib.bsu.by/handle/123456789/266304
Title: | Substituted azafluorenones: Access from dihalogeno diaryl ketones by palladium-catalyzed auto-tandem processes and evaluation of their antibacterial, antifungal, antimalarial and antiproliferative activities |
Authors: | Marquise, N. ChevallierF., Chevallier F. Nassar, E. Frederich, M. Ledoux, A. Halauko, Y.S. Ivashkevich, O.A. Matulis, V.E. Roisnel, T. Dorcet, V. Mongin, F. |
Keywords: | ЭБ БГУ::ЕСТЕСТВЕННЫЕ И ТОЧНЫЕ НАУКИ::Физика |
Issue Date: | 2016 |
Publisher: | Elsevier Ltd |
Citation: | Tetrahedron 2016;72(6):825-836. |
Abstract: | Substituted azafluorenones were synthesized from dihalogeno diaryl ketones under palladium catalysis by combining, in auto-tandem processes, Suzuki coupling and intramolecular arylation reactions. Different dihalogenated diaryl ketones, prepared by sequential deprotocupration-aroylation, were identified as suitable substrates to this purpose. Conditions were identified to allow successful syntheses of several 6-/7-arylated 4-azafluorenones, 1-substituted 4-azafluorenones, 2-phenyl-3-azafluorenone, and 4-phenyl-3-azafluorenone from 3-(bromobenzoyl)-2-chloropyridines, 3-benzoyl-4-bromo-2-chloropyridines, 4-benzoyl-2,5-dichloropyridine, and 4-benzoyl-2,3-dichloropyridine, respectively. Some of the synthesized compounds exhibit interesting biological properties. |
URI: | https://elib.bsu.by/handle/123456789/266304 |
DOI: | 10.1016/j.tet.2015.12.050 |
Scopus: | 84954393112 |
Sponsorship: | Institut Universitaire de France (IUF) |
Appears in Collections: | Статьи сотрудников НИИ ФХП |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.