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|Title:||Structurally resolved stochastic simulation model of actin polymerization|
|Authors:||Chukhutsina, V. V.|
Halavatyi, A. A.
Yatskou, M. M.
Apanasovich, V. V.
|Keywords:||ЭБ БГУ::ОБЩЕСТВЕННЫЕ НАУКИ::Информатика|
|Abstract:||Actin polymerization in cell is a basic biological process relevant to health and disease. We have developed the e±cient stochastic simulation algorithm for modelling actin dynamics regulated by actin-associated proteins. As opposed to other existing actin-cytoskeleton mathematical models, our approach is based on the advanced Monte Carlo simulation schemes and associates the main biochem- ical actin-related reactions, including multistep spontaneous actin nucleation, random and stress-induced Їlament fragmentation, with structural properties of protein Їlaments. Created algorithms were integrated into a freely available software package with user-friendly interface.|
|Appears in Collections:||Section 5. COMPUTER SIMULATION OF STOCHASTIC SYSTEMS|
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