Mutation Analysis of HIV-1 Primary Protein Sequences

Abstract

Many human immunodeficiency virus type-1 (HIV-1) infected persons are treated with multiple protease and reverse transcriptase (RT) inhibitors. Due to high variability of the virus strains these drug classes often lead to the development of drug resistance. This process is accompanied by intensive mutations in the (HIV pol gene) virus protease and reverse transcriptase. But only a subset of treatment-associated mutations is responsible for establishing drug-resistance. The proposed method is designed to detect protease and RT mutations responsible for drug-resistance surveillance and support decisions on further treatment regimen.