Разработка лекарственных средств на основе транспортной наносистемы – золотых наночастиц для адресной доставки Противоопухолевых препаратов: цисплатина и проспидина

Abstract

We studied the sorption of anticancer drugs cisplatin and prospidina colloidal gold from their aqueous solutions with concentrations corresponding to therapeutic dose. Investigation of cytotoxic activity of colloidal gold and immobilized on it cytostatics was carried out on monolayer culture of tumor cells HeLa. It is shown that the suppression of HeLa cells immobilized colloidal gold prospidina corresponds to the suppression of HeLa cells with a solution prospidina, with a significant decrease in the concentration prospidina for the immobilized colloidal gold cisplatin inhibition of HeLa cells also significantly, but less than its aqueous solutions