Comparative Analysis of Sensitizing Activity and Biodistribution Characteristics of Chlorin e6 Derivatives: Effect of the Nature of Charged Groups

Abstract

New data have been obtained that expand the understanding of the role of the chemical structure and physico-chemical properties of photosensitizer molecules in determining the processes of their interaction with various biological objects, including serum proteins, biological membranes, cells and cellular systems. Changes in the side substituents in the chlorin e6 molecule significantly affect the physico-chemical properties of new compounds, the level of their accumulation in cells, and the rate of migration between cells, but do not significantly affect the intracellular localization of sensitizers. It is assumed that the increased photosensitizing activity of chlorin e6 derivatives is due to the effect of lateral substituents on their biodistribution processes. Keywords: photosensitizers, chlorin e6 amidoderivatives, accumulation in cells, intracellular localization, photocytotoxicity.