Identification of genomic mutations associated with drug-resistant tuberculosis

Abstract

Drug resistance in tuberculosis (TB) is a global public health issue, and resistance testing early in therapy can help prevent antibiotic abuse. Data used is from the NIAID TB Portals program (https://tbportals.niaid.nih.gov). Mtb whole genome sequences from 645 patients were utilized after quality inspection. To identify mutation sites associated with drug resistance, single-marker and multi-marker tests were used. Important mutation sites associated with TB drug resistance were discovered. On the one hand, these mutation sites can give important information for understanding TB resistance, and they can be utilized for a quick screening approach for various forms of TB drug resistance