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Please use this identifier to cite or link to this item: https://elib.bsu.by/handle/123456789/265594
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dc.contributor.authorBelko, N.-
dc.contributor.authorKavalenka, S.-
dc.contributor.authorSamtsov, M.-
dc.date.accessioned2021-08-10T08:57:05Z-
dc.date.available2021-08-10T08:57:05Z-
dc.date.issued2016-
dc.identifier.citationJournal of Physics: Conference Series; 2016.ru
dc.identifier.urihttps://elib.bsu.by/handle/123456789/265594-
dc.description.abstractPhotodynamic therapy is an evolving technique for treatment of various oncological diseases. This method employs photosensitizers - species that lead to death of tumor cells after the photoactivation. For further development and novel applications of photodynamic therapy new photosensitizers are required. After synthesis of a new photosensitizer it is important to know its concentration in different biological tissues after its administration and distribution. The concentration is frequently measured by the extraction method, which has some disadvantages, e.g. it requires many biological test subjects that are euthanized during the measurement. We propose to measure the photosensitizer concentration in tissue by its fluorescence. For this purpose fluorescent standards were developed. The standards are robust and simple to produce; their fluorescence signal does not change with time. The fluorescence intensity of fluorescent standards seems to depend linearly on the dye concentration. A set of standards thus allow the calibration of a spectrometer. Finally, the photosensitizer concentration can be determined by the fluorescence intensity after comparing the corresponding spectrum with spectra of the set of fluorescent standards. A biological test subject is not euthanized during this kind of experiment. We hope this more humane technique can be used in future instead of the extraction method.ru
dc.language.isoenru
dc.publisherInstitute of Physics Publishingru
dc.subjectЭБ БГУ::ЕСТЕСТВЕННЫЕ И ТОЧНЫЕ НАУКИ::Физикаru
dc.titleFluorescent standards for photodynamic therapyru
dc.typearticleru
dc.rights.licenseCC BY 4.0ru
dc.identifier.DOI10.1088/1742-6596/735/1/012031-
dc.identifier.scopus84989836078-
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