68Ga-adsorption on the Si-nanoparticles

Abstract

In recent years, more and more attention has been paid to nanoparticles (NPs) as target drug delivery systems. Silicon-based nanoparticles are one of the most biocompatible nanomaterials that have become widespread. In this research, we studied the possibility of gallium-68 sorption on silicon (Si-SiOx) and silicon dioxide (SiO2) nanoparticles without their surface modification. Conditions allowing to obtain 68Ga-NPs with radiochemical yield ≥ 90% were found. 68Ga-SiO2 showed much higher stability over 68Ga-Si-SiOx in both in vitro and in vivo experiments.