Please use this identifier to cite or link to this item:
|Title:||Intracellular Localization and Phototoxicity Mechanisms of Chlorin e6 Derivatives and their Liposomal Formulations|
|Authors:||Zorina, T. E.|
Yankovsky, I. V.
Yakavets, I. V.
Kravchenko, I. E.
Ermilova, Т. I.
Shman, Т. V.
Belevtsev, М. V.
Zorin, V. P.
|Keywords:||ЭБ БГУ::ЕСТЕСТВЕННЫЕ И ТОЧНЫЕ НАУКИ|
|Citation:||Biophysics. – 2019. –Vol 64 (4). – P.674-685.|
|Abstract:||Confocal microscopy and colocalization analysis using Pearson correlation coefficients were used to show that esterified chlorin e6 derivatives and their liposomal forms are mainly localized in the endoplasmic reticulum, Golgi complexes, cell mitochondria, and levels of their localization in lysosomes are low. Cellular uptake and accumulation kinetics of chlorin e6 derivatives were strongly depended on the type of pharmacological formulation used for photosesitizers administration, while intracellular localization was independent on the formulation. Differences in the photodynamic activity and sensitization mechanisms for chlorin e6 derivatives and their liposomal forms were shown when compared to those of chlorin e6 photosensitizers in K562 cells. It is assumed that the observed differences in the mechanisms of cellular damage are toa greater extent due to specific photosensitizer localization.|
|Appears in Collections:||Кафедра биофизики|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.