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|Title:||Synthetic phenolic antioxidant TS-13 suppresses the growth of Lewis lung carcinoma and potentiates oncolytic effect of doxorubicin|
|Authors:||Men’shchikova, E. B.|
Zenkov, N. K.
Kozhin, P. M.
Chechushkov, A. V.
Kovner, A. V.
Khrapova, M. V.
Kandalintseva, N. V.
Martinovich, G. G.
|Keywords:||ЭБ БГУ::ЕСТЕСТВЕННЫЕ И ТОЧНЫЕ НАУКИ::Физика|
|Citation:||Bulletin of experimental biology and medicine, 2019, Vol. 166, No. 5, pp. 646-650.|
|Abstract:||ROS are important intracellular messengers; their ambiguous role in malignant processes was demonstrated in many studies. The effects of a synthetic phenolic antioxidant sodium 3-(3’-tert-butyl-4’-hydroxyphenyl)propyl thiosulfonate sodium (TS-13) on the tumor growth and oncolytic properties of doxorubicin were studied in the experimental model of Lewis lung carcinoma in mice. In mice receiving TS-13 with drinking water (100 mg/kg), suppression of tumor growth by 32.3% was observed on day 21 after inoculation of Lewis lung carcinoma cells. Two-fold intraperitoneal injections of doxorubicin in a cumulative dose of 8 mg/kg were followed by inhibition of tumor growth by 49.5%. Combined treatment with TS-13 and doxorubicin suppressed the tumor growth by 55.4%. In contrast to doxorubicin, TS-13 inhibited NO generation by peritoneal macrophages. The results show the prospect of studying TS-13 in the context of overcoming drug-resistance of tumors.|
|Appears in Collections:||Кафедра биофизики|
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