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|Title:||Effects of tryptophan derivatives and β -carboline alkaloids on radiation- and peroxide-induced transformations of ethanol|
|Authors:||Sverdlov, R. L.|
Brinkevich, S. D.
Shadyro, O. I.
|Keywords:||ЭБ БГУ::ЕСТЕСТВЕННЫЕ И ТОЧНЫЕ НАУКИ::Химия|
|Citation:||Radiation Physics and Chemistry. – 2014. – V. 98. – P. 77-85.|
|Abstract:||The subject of this study was investigation of interactions of tryptophan and its derivatives, including structurally related β-carboline alkaloids with oxygen- and carbon-centered radicals being formed during radiation- and peroxide-induced transformations of ethanol. It was shown that the above named compounds suppressed recombination and disproportionation reactions of α-hydroxyethyl radicals. The inhibitory effects of tryptophan, 5-hydroxytryptophan and serotonin were mainly realized by means of reduction and addition reactions, while those of β-carboline alkaloids – harmine, harmane and harmaline – were due to oxidation reactions. Melatonin displayed low reactivity towards α-hydroxyethyl radicals. Tryptophan derivatives and β-carboline alkaloids were found to inhibit radiation-induced oxidation of ethanol while being virtually not used up. The low transformation yields of tryptophan, 5-hydroxytryptophan and serotonin, as well as β-carboline alkaloids, indicate their capability of regeneration, which could occur on interaction of tryptophan with О−2 and НО2, or on oxidation of α-hydroxyethyl radicals by β-carboline alkaloids.|
|Appears in Collections:||Статьи химического факультета|
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