Трансдукция гормонального сигнала через аденилатциклазу печени половозрелых крыс, подвергнутых однократному пренатальному гамма-облучению

Abstract

It was found that the one-fold (0,5 Gy) prenatal gamma-irradiations on the 9th and the 15m day of embryogenesis (at the beginning and the end of organogenesis, respectively) resulted in the different alterations of glucagon signalling through the receptor/Gs-protein/adenylyl cyclase in adult rat liver. The prenatal irradiation on the 9 day enhanced the effect of GTP (the activator of Gs-protein) on the adenylyl cyclase activity. While the gamma-irradiation on the 15lh day of embryo development increased the basal, GTP- and glucagon-stimulated adenylyl cyclase activity. The results suggest that the receptor/Gs-protein/adenylyl cyclase coupling is more sensitive to low doses of gamma-irradiation performed at the end of organogenesis.