Биологическая активность сульфатов полисахаридов, синтезированных в гомогенных системах

Abstract

New methods of sulphatazation of hydroxyl-containing polymers have been worked out, using which it has become possible to obtain a large number of sulphoether-derived compounds based on natural polysaccharides(mannan, starch, dextran, sulphates). The biological activity test of 64 samples allowed to reveal sulpho-polysaccharides characterised by distinct anticoagulant and antiaggregant activity. It was demonstrated that the semisynthetic heparinoids capability to reduce the blood coagulant potential in vitro and in vivo is enhanced by the increasing of the degree of sulphating. The degree of dependence of the preparation anticoagulant effect on the level of antithrombin III, the main blood anticoagulant was established. The experimental data and the wide range of biological effect of polysaccharide-containing compounds in general are indicative of the possibility of using this group of biopolymeres for developing thrombprophylactic drugs.