Показатели эндогенной интоксикации при оценке прогрессирования рака тела матки

Abstract

Malignant tumor growth is accompanied by development of endogenous intoxication syndrome. The concentration of lipid peroxidation substrates (thiobarbituric acid reactive substances – TBARS), protein carbonyl (PC), middle molecular peptides (MMP) and conformation state of serum albumin by means of electron paramagnetic resonance (EPR-α) were analyzed in serum of 107 patients with endometrial cancer and 16 healthy individuals. The concentrations of TBARS and the means of EPR-α were significantly increased in serum of patients with endometrial cancer compared to healthy women. The increase of the level of studied parameters in patients with endometrial cancer depends on tumor grade and tumor invasion in myometrium. The studied parameters of endogenous intoxication may have predictive value for diagnosis the stage of carcinogenesis and tumor grade in endometrial cancer patients