Анализ изменений третичной структуры большого прионного белка человека при болезни крейтцфельдта-якоба

Abstract

Tertiary structures of human major prion protein have been studied in this work. The in-silico mutagenesis has been performed. All the changes in the tertiary structure of human major prion protein found in Creutzfeldt-Jacob disease were modeled. Three possible mechanisms of beta-amyloid formation in this disease have been suggested