Показатели окислительной модификации белков и липидов сыворотки крови при раке тела матки

Abstract

Malignant tumor growth is accompanied by changes of normal and abnormal metabolites in serum. The concentration of lipid peroxidation products – malone dialdehyde and protein carbonyl were analyzed in serum of 66 patients with endometrial cancer and 16 healthy individuals. The concentrations of malone dialdehyde and protein carbonyl were significantly increased in serum of patients with endometrial cancer compared to healthy women. The increase of the level of studied parameters in patients with endometrial cancer depends on tumor grade and tumor invasion in myometrium. The studied parameters of endogenous intoxication may have predictive value for diagnosis the stage of carcinogenesis and tumor grade in endometrial cancer patients