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Please use this identifier to cite or link to this item: https://elib.bsu.by/handle/123456789/21150
Title: The effect of hypoxia on photocytotoxicity of tics tricaebocyanine dye in vitro
Authors: Istomin, Y. P.
Alexandrova, E. N.
Zhavrid, E. A.
Voropay, E. S.
Samtsov, M. P.
Kaplevsky, K. N.
Lugovsky, A. P.
Lugovsky, A. A.
Keywords: ЭБ БГУ::ЕСТЕСТВЕННЫЕ И ТОЧНЫЕ НАУКИ::Физика
Issue Date: Mar-2006
Citation: Experimental Oncology. - 2006. - № 28. - С. 1-3.
Abstract: To evaluate the effect of cell oxygenation on photocytotoxicity of a novel tricarbocyanine indolenine dye covalently bound to glucose (TICS). Methods: HeLa cells were incubated with 5 µM TICS, 2 h later irradiated by laser at 740 nm with a light dose of 10 J/cm2, delivered at a power density of 10, 20, 25 or 30 mW/cm2, in air or in argon atmosphere, and then scored for viability. Results: The photocytotoxicity of TICS increased dramatically as the power density was reduced. Under hypoxia TICS-photosensitized cell death was determined but its value was lowered, compared to photoirradiation in the air. Conclusion: Photosensitizing effect of TICS is only partially dependent on the oxygenation of tumor cells.
URI: http://elib.bsu.by/handle/123456789/21150
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