Влияние гидрофобных взаимодействий на сорбцию биологически активных электролитов монокарбоксилцеллюлозой и на их высвобождение из этого носителя

Abstract

Sorption of three organical electrolytes of anticancer action (AE): spyrobromine Chlorid (SP), prospidine chlorid (PR) and hydrobromid oxythiamin bromid (ОТ) on a macromolecular bearer monocarboxylcellulose (MCC) in H+ form from water solutions at 293±1 K has been studied. The constants and Gibbs energy of the sorption process has been calculated. Estimation of hydrophobic interaction of the cation radicals with the (MCC) matrix is carried out which strength decreases by transition from (SP) and (PR) to (ОТ). The medicobiological trials on defeat animals have shown, that at treatment by a drug MCC-OT duration of life of animals increases in 2,7-3,3 times in comparison with control and at treatment by a drug MCC-SP a positive effect is not observed. Thus the received results are a basis for creation a macromolecular therapeutic system MCC-OT.