Исследование антиокислительных и антирадикальных свойств хинониминов

Abstract

In the present study antioxidant effects of two compounds N-phenyl-1,4-benzoquinonemonoimine (QMI) and N,N'-diphenyl-1,4-benzoquinonediimine (QDI) on NADPH- and CCI4-dependent lipid peroxidation in liver microsomes were investigated. We found that both quinoneimines were much stronger inhibitors of these processes as comparison with the phenolic antioxidant - butylated hydroxytoluene. It was found that each quinoneimine molecule could be involved in manifold inhibition of lipid peroxidation unlike the free radical scavengers of a phenolic type. In the following experiments, scavenging properties of QMI and QDI to Superoxide ion were elucidated. Quinoneimines are effective scavengers of Superoxide. The following values of the rate constants were obtained: k(QMI)=7,0'10s M-V , k(QDI)=3,2T05 M "V We supposed that quinoneimines are promising compounds in view of the pharmacological implication.