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https://elib.bsu.by/handle/123456789/170160| Title: | Novel indotricarbocyanine dyes covalently bonded to polyethylene glycol for theranostics |
| Authors: | Lugovski, Alexander A. Samtsov, Michael P. Kaplevsky, Kirill N. Tarasau, Dmitri Voropay, Eugene S. Petrov, Petr T. Istomin, Yuri P. |
| Keywords: | ЭБ БГУ::ЕСТЕСТВЕННЫЕ И ТОЧНЫЕ НАУКИ::Физика |
| Issue Date: | 2016 |
| Publisher: | Elsevier Science Publishing Company, Inc. |
| Citation: | Journal of Photochemistry and Photobiology A: Chemistry. - 316 (2016). - Pp. 31–36. |
| Abstract: | The synthesis methods for the indotricarbocyanine dyes covalently bonded to polyethylene glycols with varying degrees of polymerization have been developed. New indotricarbocyanine was synthesized in one step using the Mukayama reagent in polyethylene glycol with cesium fluoride as a basic catalyst. In vivo investigation of the phototherapeutic dye activity has shown selective recognition of malignant tissues, where accumulation of the dye was 4–5 times higher than in normal tissues. The necrotic area after local photoirradiation at the effective energy fluence 180 J/cm2, l = 780 nm was observed to a depth of 2.5 cm making the synthesized dyes very promising for further pharmaceutic research |
| URI: | http://elib.bsu.by/handle/123456789/170160 |
| ISSN: | 1010-6030 |
| Appears in Collections: | Статьи сотрудников НИИ ПФП |
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