NPCS Vol.14, no.3, pp. 211-318 (2011) https://elib.bsu.by:443/handle/123456789/13466 2026-04-20T09:55:56Z 2026-04-20T09:55:56Z Anishchenko, Ivan V. Andrianov, Alexander M. Tuzikov, Alexander V. https://elib.bsu.by:443/handle/123456789/13688 2021-11-12T10:59:37Z 2011-01-01T00:00:00Z

Заглавие документа: Molecular Modeling of Structural Complexes of Glycosphingolipids With the HIV-1 GP120 V3 Loop as a Framework for the Development of Anti-Aids Drugs of a New Generation Авторы: Anishchenko, Ivan V.; Andrianov, Alexander M.; Tuzikov, Alexander V. Аннотация: A sctructural complex of -galactosylceramide with the HIV-1 V3 loop peptides that imitate the most probable binding site for glycolipids was generated by molecular docking simulations. Based on the analysis of this complex, two water soluble analogs of -galactosylceramide, which should preserve a high affinity to V3 characteristic of the native molecule, were designed and their anti-HIV-1 activity was predicted by free energy calculations. In the light of the findings obtained, the simulated glycolipids may be considered as the promising basic structures for the development of novel potent antiviral agents that target (block) the envelope gp120 V3 loop.

2011-01-01T00:00:00Z Vorobjova, A. I. https://elib.bsu.by:443/handle/123456789/13687 2021-11-12T10:59:31Z 2011-01-01T00:00:00Z

Заглавие документа: Capabilities of Carbon Nanotube Utilization at Creation of Biological Sensors Авторы: Vorobjova, A. I. Аннотация: Searches of the materials adequate to designs of "clever" biosensors for biomedical applications, have led to working out of a new class of biosensors and express analyzers on the basis of new carbon materials, in particular on the basis of carbon nanotubes (CNT). In given paper the capabilities of carbon nanotube utilization at creation of biological sensors on the basis of literary analysis and own experimental results are presented. Types of carbon nanotube-based biological sensors (CNT-biosensors) and corresponding classification are considered. The basic difficulties of practical realization of different constructive-technological variants of CNT-biosensors and possibilities of their overcoming are analyzed.

2011-01-01T00:00:00Z Semenkova, G. N. Hrushevsky, V. V. Krylova, H. V. Krylova, N. G. Kulahava, T. A. Lipnevich, I. V. Orekhovskaya, T. I. Shulitsky, B. G. https://elib.bsu.by:443/handle/123456789/13686 2021-11-12T10:59:37Z 2011-01-01T00:00:00Z

Заглавие документа: Monitoring of Blood Phagocyte Functional State by Cyclic Dielectric Spectroscopy Авторы: Semenkova, G. N.; Hrushevsky, V. V.; Krylova, H. V.; Krylova, N. G.; Kulahava, T. A.; Lipnevich, I. V.; Orekhovskaya, T. I.; Shulitsky, B. G. Аннотация: The study of functional state of blood phagocytes adhering to capacity sensor surface has been carried out by cyclic dielectric spectroscopy method. The sensor dielectric coating consists of Langmuir-Blodgett monolayers with multiwall modified carbon nanotubes. The nonliner dependence of sensor capacity on cell concentration was registered. At cellular monolayer formation the Helmholtz double layer electrical field shielding effect was shown to arise. It has been established that capacity characteristics of the sensor with adhering monocytes depend on a number and cell continuity as well as ability of cells to generate reactive oxygen species. It has been shown that cell activation by adhesion and fMLP chemotactic peptide leads to increase of capacity of sensor coated by dense monocyte monolayer.

2011-01-01T00:00:00Z Korolik, E. V. Korolenko, E. A. Kasakov, F. I. Korolik, A. K. Kirkovskii, V. V. https://elib.bsu.by:443/handle/123456789/13685 2021-11-12T10:59:42Z 2011-01-01T00:00:00Z

Заглавие документа: The Fluorescent Probing Method in the Estimation of the Functional Probabilities of the Blood Plasma Transport Systems Авторы: Korolik, E. V.; Korolenko, E. A.; Kasakov, F. I.; Korolik, A. K.; Kirkovskii, V. V. Аннотация: During this work method of fluorescent probes with differently charged fluorescent dyes was used for estimation of binding ability of the blood plasma main transport proteins. Investigations were done at the patients with liver cirrhosis for creating on those basis fluorescent tests adapted for clinical use. Such tests should use for depending of severity degree of pathological process and for the correct choice of the most effective haemosorbent for extracorporeal blood purification in the definite clinical situation. Regularity was shown for the changes in the binding ability of the blood plasma main transport proteins in liver cirrhosis, which depended on the stage of the disease and allowed efficiently estimate severity degree of pathological process. Comparative evaluation of the efficacy of different charcoal haemosorbents widely used in clinical practice as well as "Prometheus" device was done in terms of endogenous intoxication syndrome correction at liver cirrhosis patients using results of biochemical analysis and method of fluorescent dyes. It was shown that the most effective sorbents were sorbents of "Prometheus" and between charcoal heamosorbents - "Carbocol".

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