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https://elib.bsu.by/handle/123456789/289964
Заглавие документа: | Application of iron-based magnetic nanoparticles stabilized with triethanolammonium oleate for theranostics |
Авторы: | Pawlik, Piotr Blasiak, Blasiak Depciuch, Joanna Pruba, Marcin Kitala, Diana Vorobyova, Svetlana Stec, Malgorzata Bushinsky, Maxim Konakov, Artem Baran, Jaroslaw Fedotova, Julia Ivashkevich, Oleg Parlinska-Wojtan, Magdalena Maximenko, Alexey |
Тема: | ЭБ БГУ::ЕСТЕСТВЕННЫЕ И ТОЧНЫЕ НАУКИ::Физика ЭБ БГУ::ЕСТЕСТВЕННЫЕ И ТОЧНЫЕ НАУКИ::Химия |
Дата публикации: | 2022 |
Издатель: | Springer; CODEN; JMTSA |
Библиографическое описание источника: | J Mater Sci 2022;57(7):4716-4737. |
Аннотация: | The novel iron-oxide nanoparticles (NPs) stabilized with triethanolammonium oleate were produced. The specimens were divided into two groups: the top NPs (extracted from the supernatant) and the bottom NPs (nanoparticles sedimented at the bottom of the flask during centrifugation), respectively. The XRD and Mössbauer studies revealed a presence of the Fe3O4 phase in both types of nanoparticles. Furthermore, the formation of maghemite layer on the surface of nanoparticles was observed. Average particle sizes determined from TEM and XRD studies were lower than the superparamagnetic limit for the magnetite NPs. For glycerol dispersions of both types of NPs, when exposed to 100 kHz external magnetic field, a significant heat release was observed. Furthermore, the contrasts of T1- and T2-weighted MR images were significantly dependent on the concentration of NPs in their water solutions. Additionally, the reductions of the relaxation times were different for the top and the bottom NPs. The viability studies of the colon cancer cells have shown low cytotoxicity of both types of NPs due to their coating with triethanolammonium oleate, which confirm the possibility to apply the NPs for MRI-guided hyperthermia. Moreover, the presence of NPs did not cause greatest increase of the number of apoptotic cells in the human dermal fibroblasts’ culture and has stimulated proliferation of those cells, revealing great potential of the NPs in regenerative medicine. Graphical abstract: |
URI документа: | https://elib.bsu.by/handle/123456789/289964 |
DOI документа: | 10.1007/s10853-021-06244-y |
Scopus идентификатор документа: | 85123820939 |
Финансовая поддержка: | The authors acknowledge the financial support from the Belarusian Republic Foundation for Basic Research (project no. X20MS-014) and National Science Centre (Poland) (project “Harmonia” no. 2018/30/M/NZ5/00844). |
Лицензия: | info:eu-repo/semantics/openAccess |
Располагается в коллекциях: | Статьи сотрудников НИИ ФХП |
Полный текст документа:
Файл | Описание | Размер | Формат | |
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s10853-021-06244-y.pdf | 2,49 MB | Adobe PDF | Открыть |
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