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Заглавие документа: Interaction of lactoferrin with unsaturated fatty acids: In vitro and in vivo study of human lactoferrin/oleic acid complex cytotoxicity
Авторы: Elizarova, Anna
Sokolov, Alexey
Kostevich, Valeria
Kisseleva, Ekaterina
Zelenskiy, Evgeny
Zakharova, Elena
Panasenko, Oleg
Budevich, Alexander
Semak, Igor
Egorov, Vladimir
Pontarollo, Giulia
De Filippis, Vincenzo
Vasilyev, Vadim
Тема: ЭБ БГУ::ЕСТЕСТВЕННЫЕ И ТОЧНЫЕ НАУКИ::Химия
Дата публикации: 2021
Издатель: MDPI AG
Библиографическое описание источника: Mater 2021;14(7).
Аннотация: As shown recently, oleic acid (OA) in complex with lactoferrin (LF) causes the death of cancer cells, but no mechanism(s) of that toxicity have been disclosed. In this study, constitutive parameters of the antitumor effect of LF/OA complex were explored. Complex LF/OA was prepared by titrating recombinant human LF with OA. Spectral analysis was used to assess possible structural changes of LF within its complex with OA. Structural features of apo-LF did not change within the complex LF:OA = 1:8, which was toxic for hepatoma 22a cells. Cytotoxicity of the complex LF:OA = 1:8 was tested in cultured hepatoma 22a cells and in fresh erythrocytes. Its anticancer activity was tested in mice carrying hepatoma 22a. In mice injected daily with LF-8OA, the same tumor grew significantly slower. In 20% of animals, the tumors completely resolved. LF alone was less efficient, i.e., the tumor growth index was 0.14 for LF-8OA and 0.63 for LF as compared with 1.0 in the control animals. The results of testing from 48 days after the tumor inoculation showed that the survival rate among LF-8OA-treated animals was 70%, contrary to 0% rate in the control group and among the LF-treated mice. Our data allow us to regard the complex of LF and OA as a promising tool for cancer treatment.
URI документа: https://elib.bsu.by/handle/123456789/289114
DOI документа: 10.3390/ma14071602
Scopus идентификатор документа: 85103821593
Финансовая поддержка: Funding: This research was funded by the Russian Presidential Grant for young Ph.D. number MK-5074.2016.4; and was supported in part by a grant from the CaRiPaRo Foundation Excellence Research Project BPiTA number 52012 to V.D.F.
Лицензия: info:eu-repo/semantics/openAccess
Располагается в коллекциях:Статьи биологического факультета

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