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https://elib.bsu.by/handle/123456789/287997
Заглавие документа: | Optical properties of photodynamic therapy drugs in different environments: The paradigmatic case of temoporfin |
Авторы: | Aslanoglu, B. Yakavets, I. Zorin, V. Lassalle, H.-P. Ingrosso, F. Monari, A. Catak, S. |
Тема: | ЭБ БГУ::ТЕХНИЧЕСКИЕ И ПРИКЛАДНЫЕ НАУКИ. ОТРАСЛИ ЭКОНОМИКИ::Медицина и здравоохранение ЭБ БГУ::ЕСТЕСТВЕННЫЕ И ТОЧНЫЕ НАУКИ::Биология ЭБ БГУ::ЕСТЕСТВЕННЫЕ И ТОЧНЫЕ НАУКИ::Физика |
Дата публикации: | 2020 |
Издатель: | Royal Society of Chemistry CODEN PPCPF |
Библиографическое описание источника: | Phys Chem Chem Phys 2020;22(29):16956-16964 |
Аннотация: | Computational tools have been used to study the photophysical and photochemical features of photosensitizers in photodynamic therapy (PDT)-a minimally invasive, less aggressive alternative for cancer treatment. PDT is mainly based on the activation of molecular oxygen through the action of a photoexcited sensitizer (photosensitizer). Temoporfin, widely known as mTHPC, is a second-generation photosensitizer, which produces the cytotoxic singlet oxygen when irradiated with visible light and hence destroys tumor cells. However, the bioavailability of the mostly hydrophobic photosensitizer, and hence its incorporation into cells, is fundamental to achieve the desired effect on malignant tissues via PDT. In this study, we focus on the optical properties of the temoporfin chromophore in different environments-in vacuo, in solution, encapsulated in drug delivery agents, namely cyclodextrin, and interacting with a lipid bilayer. This journal is © the Owner Societies. |
URI документа: | https://elib.bsu.by/handle/123456789/287997 |
DOI документа: | 10.1039/d0cp02055a |
Scopus идентификатор документа: | 85088881079 |
Финансовая поддержка: | Calculations were partially performed at the TUBITAK ULAKBIM High Performance and Grid Computing Center (TRUBA resources), the LPCT (www.lpct.univ-lorraine.fr) local computing resources as well as the computational resources at CCBG (www.ccbg.boun.edu.tr) funded by the Bogazici University Research Fund (BAP-SUP Project No. 8245). The authors thank biolitec research GmbH (Jena, Germany) for providing with mTHPC |
Лицензия: | info:eu-repo/semantics/openAccess |
Располагается в коллекциях: | Кафедра биофизики (статьи) |
Полный текст документа:
Файл | Описание | Размер | Формат | |
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d0cp02055a.pdf | 2,74 MB | Adobe PDF | Открыть |
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